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ea0029p1372 | Pituitary Clinical | ICEECE2012

Effects of previous GH excess and current medical treatment for acromegaly on cognition

Brummelman P. , Koerts J. , Dullaart R. , van den Berg G. , Tucha O. , Wolffenbuttel B. , van Beek A.

Context: In untreated acromegalic patients, decreased cognitive functioning is reported to be associated with the degree of GH and IGF1 excess. Whether previous GH excess or current medical treatment for acromegaly specifically affects cognition remains unclear.Objective: To compare cognitive functioning in patients who are treated for acromegaly and non-functioning pituitary adenomas (NFA). In addition, we assessed the influence of prolonged medical tre...

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ea0056oc7.5 | Genomic and clinical aspects of endocrine tumours | ECE2018

Randomized trial comparing phenoxybenzamine and doxazosine for preoperative treatment of patients with a pheochromocytoma (PRESCRIPT)

Buitenwerf E , Osinga TE , Timmers HJLM , Lenders JWM , Feelders RA , Eekhoff EMW , Haak HR , Corssmit EPM , Bisschop PHLT , Valk GD , GrooteVeldman R , Dullaart RPF , Links TP , Voogd MF , Wietasch JKG , Kerstens MN

Background: Administration of α-adrenergic receptor antagonists is recommended before resection of a pheochromocytoma (PCC) in order to prevent perioperative cardiovascular complications. For this purpose either phenoxybenzamine (PXB) or doxazosin (DOX) is commonly prescribed. We conducted the first randomized controlled trial comparing the efficacy of PXB and DOX in controlling perioperative hemodynamics in patients undergoing PCC resection (ClinicalTrials.gov:NCT0137989...

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Endocrine Abstracts

Effects of previous GH excess and current medical treatment for acromegaly on cognition

Randomized trial comparing phenoxybenzamine and doxazosine for preoperative treatment of patients with a pheochromocytoma (PRESCRIPT)

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